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Innentitelbild: Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target (Angew. Chem. 9/2010)

✍ Scribed by Maxwell D. Cummings; Jimmy Lindberg; Tse-I Lin; Herman de Kock; Oliver Lenz; Elisabet Lilja; Sara Felländer; Vera Baraznenok; Susanne Nyström; Magnus Nilsson; Lotta Vrang; Michael Edlund; Åsa Rosenquist; Bertil Samuelsson; Pierre Raboisson; Kenneth Simmen

Book ID
102723393
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
583 KB
Volume
122
Category
Article
ISSN
0044-8249

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Inside Cover: Induced-Fit Binding of the
Inside Cover: Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target (Angew. Chem. Int. Ed. 9/2010)
✍ Maxwell D. Cummings; Jimmy Lindberg; Tse-I Lin; Herman de Kock; Oliver Lenz; Eli 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 614 KB

The anti-HCV activity … … of TMC435, currently in phase 2b clinical studies as an HCV therapeutic (HCV = hepatitis C virus), is based on inhibition of the NS3/4A protease of the virus. As M. D. Cummings and co-workers describe in their Communication on page 1652 ff., binding of TMC435 to the target