Innate immune detection of microbial nucleic acids
✍ Scribed by Gürtler, Claudia; Bowie, Andrew G.
- Book ID
- 120405591
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 594 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0966-842X
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## Abstract Viral infections are detected by sensor molecules, which initiate innate antiviral responses, including the activation of type I interferons (IFNs) and proinflammatory cytokines. These cytokines are responsible for not only inhibiting viral replication in infected cells but also regulat
During infection or tissue damage, the innate immune system detects and responds to nucleic acids released from pathogens or damaged host cells. Accumulating evidence has showed that specific sequences, modifications or structures of nucleic acids influence their immunomodulatory activities. Resulti