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Injections of 6-hydroxydopamine into the ventral tegmental area destroy mesolimbic dopamine neurons but spare the locomotor activating effects of nicotine in the rat

✍ Scribed by Vezina, P.; Hervé, D.; Glowinski, J.; Tassin, J.P.


Book ID
122839465
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
365 KB
Volume
168
Category
Article
ISSN
0304-3940

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✍ S. B. Blunt; Dr. P. Jenner; C. D. Marsden 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 784 KB

## Abstract Ever since the introduction of levo‐3, 4‐dihydroxyphenylalanine (L‐dopa) for the treatment of Parkinson's disease, there has been concern that it might accelerate the degeneration of dopamine neurones. Using rats with a unilateral 6‐hydroxydopamine (6‐OHDA) lesion of the medial forebrai