Injectable hydrogels for bone and cartilage repair
β Scribed by Amini, Ashley A; Nair, Lakshmi S
- Book ID
- 115456973
- Publisher
- Institute of Physics
- Year
- 2012
- Tongue
- English
- Weight
- 548 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1748-6041
No coin nor oath required. For personal study only.
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## Abstract Articular cartilage is a highly hydrated tissue with depthβdependent cellular and matrix properties that provide lowβfriction load bearing in joints. However, the structure and function are frequently lost and there is insufficient repair response to regenerate highβquality cartilage. S
Injectable hydrogels based on hyaluronic acid (HA) and poly(ethylene glycol) (PEG) were designed as biodegradable matrices for cartilage tissue engineering. Solutions of HA conjugates containing thiol functional groups (HA-SH) and PEG vinylsulfone (PEG-VS) macromers were cross-linked via Michael add