Injectable biomaterials for incontinence and vesico-ureteral reflux: Current status and future promise
✍ Scribed by Chi-Chun Tsai; Victor Lin; Liping Tang
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 279 KB
- Volume
- 77B
- Category
- Article
- ISSN
- 1552-4973
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✦ Synopsis
Abstract
Many injectable biomaterials have been produced as bulking agents for compression of urethral sphincter or ureteral orifice for treating adult stress incontinence or vesico‐ureteral reflux in pediatrics. The agents being developed include glutaraldehyde crosslinked collagen, dextranomer/hyaluronic acid copolymer, pyrolytic carbon‐coated zirconium oxide beads, polydimethyl‐siloxane microparticles, polytetrafluoroethylene paste, autologous fats, autologous chondrocytes, and others. Though less invasive nature of these agents has gained their popularity as a quick solution of the disease symptoms, most of such treatments fail to produce good long‐term efficacy. The failure is likely caused by the rapid degradation of material implants and the lack of tissue regeneration/integration properties. We thus believe that a good injectable biomaterial for incontinence should possess the following two properties: (1) to resist degradation and to reside in the implantation sites for a long period of time or (2) to enhance tissue regeneration and to establish permanent periurethral or subureteric tissue. Here we report some recent results for supporting this hypothesis. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006