Injectable acrylic bone cements for vertebroplasty with improved properties

✍ Scribed by Carrodeguas, Ra�l Garc�a ;Lasa, Blanca V�zquez ;del Barrio, Julio San Rom�n

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 407 KB
• Volume: 68B
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.b.20007

✦ Synopsis

Abstract

Currently commercially available acrylic bone cements lack adequate radiopacity and viscosity when they are used in percutaneous vertebroplasty (PVP). In this work improved formulations of radiopaque and injectable poly(methyl methacrylate) bone cements were prepared with different amounts (10–50 wt.%) of BaTiO~3~ or SrTiO~3~ particles as the radiopaque agent. Two sets of cements were prepared by using untreated or silanated radiopaque particles, respectively. The influence of the content and nature of the radiopaque agent as well as its silanation with 3‐(trimethoxysilyl) propyl methacrylate (γ‐MPS), on the curing parameters, residual monomer content, radiopacity, mechanical properties, and injectability of the resulting materials, was examined. Doughing and setting times, maximum temperature, and compressive strength of all formulations fulfilled the requirements of standard specifications, with values of peak temperature in the range 57–72 °C and those of compressive strength between 114 and 135 MPa. Formulations containing at least 20 wt.% BaTiO~3~ or SrTiO~3~ had radiopacities equal to or greater than that corresponding to 2 mm of Al as required for surgical plastics. Injectability of any of the formulations provided 75–80 wt.% of the total mass manually injected through a conventional biopsy needle 4 min after mixing. Silanation of the BaTiO~3~ or SrTiO~3~ particles led to formulations with improved mechanical properties and injectability compared to those obtained with the untreated fillers. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 68B: 94–104, 2004