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Initiation of V(D)J recombination invivo: role of recombination signal sequences in formation of single and paired double-strand breaks

✍ Scribed by Steen, S. B.


Book ID
111744757
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
343 KB
Volume
16
Category
Article
ISSN
0261-4189

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The end-joining pathway of DNA double-strand break (DSB) repair is necessary for proper V(D)J recombination and repair of DSB caused by ionizing radiation. This DNA repair pathway can either use short stretches of (micro)homology near the DNA ends or use no homology at all (direct end-joining). We d