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Initiation of Rapid, P53-Dependent Growth Arrest in Cultured Human Skin Fibroblasts by Reactive Chlorine Species

โœ Scribed by Glenn F. Vile; Lincoln A. Rothwell; Anthony J. Kettle


Book ID
117978367
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
120 KB
Volume
377
Category
Article
ISSN
0003-9861

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Initiation of Rapid, P53-Dependent Growt
โœ Glenn F. Vile; Lincoln A. Rothwell; Anthony J. Kettle ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 120 KB

Oxidants produced by neutrophils have been implicated in causing cancers associated with chronic inflammation. Hypochlorous acid is the most potent oxidant produced by these cells in appreciable amounts. It reacts with amines to form chloramines, which are weaker oxidants but are mutagenic. Recently