✍ Scribed by Katsuhiro Ogawa; Kinya Yokokawa; Takashi Tomoyori; Masanobu Narasaki
No coin nor oath required. For personal study only.
Administration of ethylnitrosourea (ENU) to pregnant rats in the late stage of gestation has been known to have a mainly neurocarcinogenic action on the progeny. However, when transplacental administration of ENU was combined in postnatal life with a brief dietary exposure to 2-acetylaminofluorene (2-AAF) and a two-thirds partial hepatectomy, numerous focal hyperplastic lesions of y-glutamyltranspeptidase (GGT)-positive hepatocytes emerged in the liver of the progeny. On the other hand, rats of F, generation born of F, parents and F, rats born of F2 parents showed no increase in the incidence of hepatic lesions after treatment with the same dietary regimen. It was suggested that direct interaction between fetal liver cells and the carcinogen is important for Occurrence of initiated hepatocytes and that the initiation effect on rat liver by ENU does not persist in the descendants of F, and F, generations.
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