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Initiation and propagation of Shh signaling during limb development

✍ Scribed by Antonella Galli; Lia Panmann; Marco Osterwalder; Dimitri Robay; Rolf Zeller

Book ID
116976360
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
50 KB
Volume
306
Category
Article
ISSN
0012-1606

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The zone of polarizing activity (ZPA) is a specialized region involved in the antero-posterior (A-P) axis formation in chick and mouse limb buds. The existence of ZPA in the posterior margin is suggested in Xenopus hindlimb buds because 180Β°rotation of the distal limb tip induces the supernumerary l