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Initial stages of endogenous DNA degradation in rat liver nuclei isolated and incubated in the presence of Mg2+ or polyamines

โœ Scribed by Ludmila Kokileva


Book ID
107770274
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
563 KB
Volume
13
Category
Article
ISSN
0020-711X

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โœ Meerman, John H. N. ;Tijdens, Roeline B. ;Mulder, Gerard J. ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 580 KB

The covalent binding of reactive metabolites of the carcinogen N-hydroxy-2-acetylaminofluorene to DNA and protein in isolated, intact rat liver nuclei was studied. The chemically synthesized 2-acetylaminofluorene-N-sulfate became covalently bound to DNA and protein to form adducts, 50% to 60% of whi