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Initial expression of interferon alpha receptor 2 (IFNAR2) on CD34-positive cells and its down-regulation correlate with clinical response to interferon therapy in chronic myelogenous leukemia

✍ Scribed by Kinro Ito; Hideo Tanaka; Takuo Ito; Tanvira A. Sultana; Taiichi Kyo; Fumio Imanaka; Yasukazu Ohmoto; Akiro Kimura


Book ID
114792680
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
358 KB
Volume
73
Category
Article
ISSN
0902-4441

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Natural and recombinant interferons (IFNs) have already demonstrated therapeutic efficacy, including cytogenetic re- missions, in patients with chronic myelocytic leukemia (CML). We investigated at the level of ligand-receptor interaction the question whether heterogeneity of receptor number or affi