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Initial clinical experience with helical tomotherapy for head and neck cancer

✍ Scribed by Allen M. Chen; Richard L. S. Jennelle; Radhika Sreeraman; Claus C. Yang; Tianxiao Liu; Srinivasan Vijayakumar; James A. Purdy

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
153 KB
Volume
31
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background.

To report a single‐institutional experience with the use of helical tomotherapy (HT)‐based intensity‐modulated radiotherapy (IMRT) for head and neck cancer.

Methods.

Seventy‐seven consecutive patients were treated with HT for squamous cell carcinoma of the head and neck to a median dose of 66 Gy (range, 60 to 72 Gy). Megavoltage CT scans were obtained as part of an image‐guided registration protocol for patient alignment before each treatment. Concurrent chemotherapy was administered to 48 patients (62%).

Results.

The 2‐year estimates of overall survival, local‐regional control, and disease‐free survival were 82%, 77%, and 71%, respectively. Spatial evaluation of local‐regional failures revealed that 16 of the 18 patients who progressed in the primary site or neck failed in the high‐dose planning target volume (PTV).

Conclusions.

HT appears to achieve clinical outcomes comparable to contemporary series reporting on IMRT for head and neck cancer. © 2009 Wiley Periodicals, Inc. Head Neck, 2009

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