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Inhibitory Specificity Change of the Ovomucoid Third Domain of the Silver Pheasant upon Introduction of an Engineered Cys 14 −Cys 39 Bond ‡

✍ Scribed by Hemmi, Hikaru; Kumazaki, Takashi; Yamazaki, Toshimasa; Kojima, Shuichi; Yoshida, Takuya; Kyogoku, Yoshimasa; Katsu, Masataka; Shinohara, Fumikazu; Yokosawa, Hideyoshi; Miura, Kin-ichiro; Kobayashi, Yuji

Book ID: 126845468
Publisher: American Chemical Society
Year: 2003
Tongue: English
Weight: 187 KB
Volume: 42
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi026727c

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Increasing the hydrolysis constant of th

Increasing the hydrolysis constant of the reactive site upon introduction of an engineered Cys14Cys39 bond into the ovomucoid third domain from silver pheasant

✍ Hikaru Hemmi; Takashi Kumazaki; Shuichi Kojima; Takuya Yoshida; Tadayasu Ohkubo; 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB

## Abstract P14C/N39C is the disulfide variant of the ovomucoid third domain from silver pheasant (OMSVP3) introducing an engineered Cys^14^Cys^39^ bond near the reactive site on the basis of the sequence homology between OMSVP3 and ascidian trypsin inhibitor. This variant exhibits a narrower inhi