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Inhibitory potential of nonsteroidal anti-inflammatory drugs on UDP-glucuronosyltransferase 2B7 in human liver microsomes

✍ Scribed by Yuji Mano; Takashi Usui; Hidetaka Kamimura


Publisher
Springer
Year
2007
Tongue
English
Weight
155 KB
Volume
63
Category
Article
ISSN
0031-6970

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The inhibitory potencies of non-steroidal anti-inflammatory drugs (NSAIDs) on UDP-glucuronosyltransferase (UGT) 1A9 activity were investigated in recombinant human UGT1A9 using 4-methylumbelliferone (4-MU) as a substrate for glucuronidation. 4-MU glucuronidation (4-MUG) showed Michaelis-Menten kinet