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Inhibitory Effects on Cytochrome P450 Enzymes of Pentamidine and Its Amidoxime Pro-Drug

✍ Scribed by Anja Bürenheide; Thomas Kunze; Bernd Clement

Book ID
111316494
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
138 KB
Volume
103
Category
Article
ISSN
1742-7835

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The interaction of antiparasitic drugs with the polymorphic cytochrome P450 2D6 was studied in human liver microsomes. Of ten different drugs tested, three quinolines, oxamniquine, primaquine and chloroquine inhibited microsomal CYP2D6-catalysed formation of l'hydroxybufuralol at concentrations tha