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Inhibitory effects on collagen accumulation in cultured scleroderma fibroblasts by tumor necrosis factor-alpha (TNF-α)

✍ Scribed by Takeda, Koji; Hatamochi, Atsushi; Ueki, Hiroaki


Book ID
123034848
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
108 KB
Volume
2
Category
Article
ISSN
0923-1811

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Recent studies have demonstrated that tumor necrosis factor-alpha (TNF-alpha) selectively decreases production of collagens I and III, the major types of collagen in the dermis, and increases production of collagenase in cultured dermal fibroblasts. The effects of TNF-alpha on collagens I, III and V