Inhibitory effects of secretin on gastrin-stimulated rat colon neoplasms

Inhibitory effect of the novel anti-estr

Inhibitory effect of the novel anti-estrogen EM-800 and medroxyprogesterone acetate on estrone-stimulated growth of dimethylbenz[a]anthracene-induced mammary carcinoma in rats

✍ Shouqi Luo; Milos Stojanovic; Claude Labrie; Fernand Labrie 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 153 KB 👁 1 views

The novel anti-estrogen EM-800 and medroxyprogesterone acetate (MPA) inhibit estrone (E 1 )-stimulated growth of dimethylbenz[a]anthracene (DMBA)-induced mammary tumors in a rat model. After 65 days, ovariectomy (OVX) decreased total tumor area to 9.6 ؎ 3.9% of initial size, while E 1 (1.0 µg, s.c.,