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Inhibitory Effects of (−)-Epigallocatechin Gallate on the Mutation, DNA Strand Cleavage, and DNA Adduct Formation by Heterocyclic Amines

✍ Scribed by Arimoto-Kobayashi, Sakae; Inada, Naomi; Sato, Yasuko; Sugiyama, Chitose; Okamoto, Keinosuke; Hayatsu, Hikoya; Negishi, Tomoe

Book ID
126265507
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
77 KB
Volume
51
Category
Article
ISSN
0021-8561

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## Abstract Dietary heterocyclic aromatic amines (HCA) and polyunsaturated fatty acids (PUFA) are both believed to play a role in colon carcinogenesis, and are both substrate for the enzyme cyclooxygenase (COX). In HCA‐7 cells, highly expressing isoform COX‐2, we investigated the effects of PUFA on