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Inhibitory effects of cytotoxicity of cytokine activated and expanded human CD8+ T cells by a human NKG2D alternative splice variant

✍ Scribed by M.A. Karimi; T. Cao; L. Soares; R.S. Negrini

Book ID: 116277980
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 58 KB
Volume: 11
Category: Article
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2004.12.023

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## Abstract Treatment with anti‐CD3 mAb modulates immune responses that cause type 1 diabetes and other diseases. CD8^+^ Tregs can be induced in vitro and in vivo by mAb. However, 1/3 of patients do not respond to drug therapy and in an equal proportion, anti‐CD3 mAb does not induce Tregs in vitro.