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Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport

โœ Scribed by Miki Katoh; Miki Nakajima; Hiroshi Yamazaki; Tsuyoshi Yokoi

Book ID
114301845
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
526 KB
Volume
12
Category
Article
ISSN
0928-0987

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Species differences of inhibitory effect
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โœ Naoto Suzuyama; Miki Katoh; Toshiyuki Takeuchi; Sumie Yoshitomi; Tomoaki Higuchi ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 277 KB

Previously, we clarified the species differences in P-glycoprotein (P-gp)mediated drug transport activity using human MDR1, monkey MDR1, canine MDR1, rat MDR1a, rat MDR1b, mouse mdr1a, and mouse mdr1b transfected LLC-PK 1 cell lines. However, the species differences in the inhibitory effects on P-gp