✦ LIBER ✦

Inhibitory effects of Cordia spinescens extracts and their constituents on reverse transcriptase and protease from human immunodeficiency virus

✍ Scribed by Yasmina Aura Lim; Shiho Kojima; Norio Nakamura; Hirotsugu Miyashiro; Hirotoshi Fushimi; Katsuko Komatsu; Masao Hattori; Kunitada Shimotohno; Mahabir P. Gupta; Mireya Correa

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 94 KB
Volume: 11
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199711)11:7<490::aid-ptr134>3.0.co;2-y

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✦ Synopsis

By bioactive-guided fractionation of a water extract of Cordia spinescens, magnesium lithospermate (1), calcium rosmarinate (2) and magnesium rosmarinate (3) were isolated as potent inhibitory substances against HIV-1 reverse transcriptase (RT) with IC 50 values of 0.8, 5.8 and 3.1 M, respectively. However, they were weak HIV-1 protease (PR) inhibitors with IC 50 > 100 M. The RT inhibition by these compounds was noncompetitive with respect to dTTP substrate.

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