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Inhibitory effects of 3′-methyl-3-hydroxy-chalcone on proliferation of human malignant tumor cells and on skin carcinogenesis

✍ Scribed by Yoshiko Satomi

Book ID
102864376
Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
956 KB
Volume
55
Category
Article
ISSN
0020-7136

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✦ Synopsis

3'-methyl-3-hydroxy-chalcone (3'Me-34). a derivative of chalcone, inhibited the proliferation of various kinds of human malignant tumor cells, such as HGC-27 (gastric cancer), HeLa (cervical carcinoma), PANC-I (pancreatic cancer) and GOTO (neuroblastoma). Flow-cytometric analysis of HGC-27 cells revealed that 3'Me-3-C perturbed the cell cycle, i.e., it delayed passage through the S phase, and/or caused arrest in the Go/GI phase. 3'Me-3-C inhibited the binding of [6,7-3H]estradiol to type4 estrogen-binding sites dose-dependently, and altered the pattern of protein synthesis and phosphorylation, which may explain 3'Me-3-C-induced inhibition of cell proliferation. In addition, 3'Me-3-C also suppressed the promoting activity of 12-0-tetradecanoylphorbol-13-acetate on skin carcinogenesis in 7, I2-dimethylbenz[a]anthracene-initiated mice.

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