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Inhibitory effect of zinc-protoporphyrin on the induction of heme oxygenase and the associated decrease in cytochrome P-450 content in rats

โœ Scribed by Yoichi Matsuura; Teruo Fukuda; Takemi Yoshida; Yukio Kuroiwa

Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
827 KB
Volume
50
Category
Article
ISSN
0300-483X

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Dextromethorphan (DXM) is commonly used as a probe for the metabolic activity of the debrisoquine isozyme (P-450 lID6) of the cytochrome P-450 mixed-function oxidase system. Several reports have described changes in P-450 activity with dietary alteration. This study was conducted to determine the ef