Inhibitory effect of two newer antidepressants, Lu 5-003 and Lu 3-010, on serotonin uptake in human blood platelets in vitro
✍ Scribed by O. Lingjærde
- Publisher
- Springer
- Year
- 1970
- Tongue
- English
- Weight
- 368 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0033-3158
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✦ Synopsis
Lu 5-003 (1-[3-methylaminopropylJ-l-phenyl-3,3-dimethyl-thiophthalane hydroehloride) and Lu 3--010 (the corresponding phthalane derivative) are two newer drugs currently under investigation for antidepressant properties. Their inhibitory effect on 5-hydroxytryptamine (serotonin) uptake in human blood platelets in vitro have been studied in comparison with some well-known trieyelic antidepressants. The newer drugs were found to be about 10 times less potent in this respect than imipramine and amitriptyline, and several times less potent than desipramine and nortriptyline. The inhibitory effect of Lu 5-003 was found to be of the competitive type. The possible correlation between inhibitory effects on the '~ pump" and the antidepressant effect is discussed briefly.