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Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages

✍ Scribed by S J Smith; P S Fenwick; A G Nicholson; F Kirschenbaum; T K Finney-Hayward; L S Higgins; M A Giembycz; P J Barnes; L E Donnelly

Book ID: 110009274
Publisher: Nature Publishing Group
Year: 2006
Tongue: English
Weight: 329 KB
Volume: 149
Category: Article
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0706885

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## Abstract Oxidative stress in the brain has been increasingly associated with the development of numerous human neurological diseases. Microglia, activated upon neuronal injury or inflammatory stimulation, are known to release superoxide anion (^·^O), hydrogen peroxide (H~2~O~2~), and nitric oxid