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Inhibitory effect of mizoribine on matrix metalloproteinase-1 production in synovial fibroblasts and THP-1 macrophages

✍ Scribed by Binbin Zhong; Michiko Tajima; Hidenari Takahara; Hiromi Nochi; Koichi Tamoto; Naoto Tamura; Shigeto Kobayashi; Yoshifumi Tamura; Makoto Ikeda; Tomohiro Akimoto; Shinichi Yoshino; Hiroshi Hashimoto

Book ID
106291762
Publisher
Springer
Year
2005
Tongue
English
Weight
214 KB
Volume
15
Category
Article
ISSN
1439-7595

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## Abstract ## Objective To investigate whether retroviral gene transfer of ribozymes targeting matrix metalloproteinase 1 (MMP‐1) inhibits the production of MMP‐1 in rheumatoid arthritis synovial fibroblasts (RASFs) and reduces the invasiveness of these cells in vivo. ## Methods MMP‐1–specific