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Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan

✍ Scribed by Tzu-Yu Lin; Cheng-Wei Lu; Su-Jane Wang


Book ID
116765278
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
605 KB
Volume
54
Category
Article
ISSN
0197-0186

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## Abstract Presynaptic 5‐HT~2A~ receptor modulation of glutamate release from rat cerebrocortical nerve terminals (synaptosomes) was investigated by using the 5‐HT~2A/2C~ receptor agonist (Β±)‐1‐[2,5‐dimethoxy‐4‐iodophenyl]‐2‐aminopropane (DOI). DOI potently inhibited 4‐aminopyridine (4AP)‐evoked g