Inhibitory effect of Cordyceps sinensis and Cordyceps militaris on human glomerular mesangial cell proliferation induced by native LDL
✍ Scribed by Wu Zhao-Long; Wang Xiao-Xia; Cheng Wei-Ying
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 80 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0263-6484
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✦ Synopsis
Native LDL, in low concentrations, promotes proliferation of cultured human glomerular mesangial cells. LDL stimulated [ 3 H]-thymidine incorporation into DNA of human glomerular mesangial cells. Increased concentrations of LDL led to increased [ 3 H]-thymidine incorporation. When LDL concentrations were 5, 10 and 50 mg ml À1 , [ 3 H]thymidine incorporation was 919 . 5+216, 1106+132, and 1200+210, respectively. When Cordyceps sinensis 100, 200, 300, 400 mg ml À1 plus LDL 10 mg ml À1 were added, [ 3 H]-thymidine incorporation was 99+19 and 53+8, respectively, P 5 0 . 01 compared with controls. With Cordyceps militaris at similar concentrations plus LDL 10 mg ml À1 , [ 3 H]-thymidine incorporation was respectively 192+75, 168+66, 145+53 and 72+16, P 5 0 . 01 compared with controls. The data suggest that LDL may play a critical role in mediating mesangial cell hypertrophy or proliferation involved in the development of glomerulosclerosis. Cordyceps sinensis and Cordyceps militaris inhibited, to a certain degree, proliferation of cultured human glomerular mesangial cell induced by LDL.