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Inhibitory effect of calf fetuin on the cytotoxic activity of LAK cell-derived factors and tumor necrosis factor

✍ Scribed by O.Yu. Chertov; M.V. Ermolaeva; D.K. Satpaev; L.P. Saschenko; O.D. Kabanova; E.M. Lukanidin; T.I. Lukjianova; I.V. Redchenko; L.Yu. Blishchenko; N.V. Gnuchev


Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
267 KB
Volume
42
Category
Article
ISSN
0165-2478

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The effects of the tumor necrosis factor (TNF), and a second pleiotropic cytokine interferon-gamma (IFN), were examined in a line of human myeloblastic leukemia cells (ML-1). By itself, TNF causes ML-1 to differentiate along the monocytic pathway. The cells exhibit an increase in Fc receptors and ac