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Inhibitory effect of a nucleoside analog, acyclovir, on leukemia cells

โœ Scribed by Jiroh Nishimaki; Keisuke Miyazawa; Akihiko Gotoh; Osamu Yoshikawa; Kazuma Ohyashiki; Keisuke Toyama

Book ID
113240189
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
891 KB
Volume
20
Category
Article
ISSN
0145-2126

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Gemcitabine (2',2'difluoro-2'deoxycytidine, dFdC) is a synthetic antimetabolite of the cellular pyrimidine nucleotide metabolism. In a first series of in vitro experiments, the drug showed a strong effect on the proliferation and colony formation of the human androgen-sensitive tumor cell line LNCaP