The compound 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a potent inhibitor of a number of viruses in vitro such as human immunodeficiency virus types 1 and 2, herpes simplex virus types 1 and 2, hepatitis B virus, cytomegalovirus, and Epstein-Barr virus. PMEA also proved to be effective in vivo a
Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) on human and duck hepatitis B virus infection
โ Scribed by R.A. Heijtink; G.A. De Wilde; J. Kruining; L. Berk; J. Balzarini; E. De Clercq; A. Holy; S.W. Schalm
- Book ID
- 118393025
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 873 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0166-3542
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9-(2-Phosphonylmethoxyethyl)adenine (PMEA), a potent inhibitor of human immunodeficiency virus (HIV), caused a dore-dependent suppression of tumor formation, and mortality associated therewith, in 6-day-old NMRI mice inoculated intracerebrally with Moloney murine sarcoma virus (MSV). Even at a dose