Inhibitory actions of amino acids in the preoptic-anterior hypothalamus of the rat
β Scribed by M. L. Mayer
- Publisher
- Springer-Verlag
- Year
- 1981
- Tongue
- English
- Weight
- 360 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0014-4819
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β¦ Synopsis
Extracellular recordings were made from preoptic-anterior hypothalamic neurones with combined recording and iontophoresis electrodes. Short iontophoretic applications of beta-alanine, GABA, glycine and taurine inhibited the discharge of the majority of neurones tested. Bicuculline metho-chloride reversibly and selectively antagonised GABA responses. Strychnine reversibly antagonised beta-alanine, glycine and taurine but not GABA responses. These results suggest the existence of two populations of inhibitory amino acid receptors in the preoptic-anterior hypothalamus. The function of inhibitory amino acids in the rostral hypothalamus was briefly discussed.
π SIMILAR VOLUMES
The preoptic area/anterior hypothalamus (POA/AH) sits as a boundary region rostral to the classical diencephalic hypothalamus and ventral to the telencephalic septal region. Numerous studies have pointed to the region's importance for sex-dependent functions. Previous studies suggested that migrator