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Inhibitory action of BHA on carcinogenesis in F1 and F2 descendants of mice exposed to DMBA during pregnancy

✍ Scribed by A. Ramesha Rao

Publisher: John Wiley and Sons
Year: 1982
Tongue: French
Weight: 410 KB
Volume: 30
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910300120

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✦ Synopsis

Administration of 500 pg of DMBA to female mice during late pregnancy results in the occurrence of tumors in F, and F, generation individuals. F, progeny had a higher percentage of tumor-bearing individuals than the F, progeny. All the five litters of F, females displayed tumor risk but the risk declined progressively in successive litters. Perinatal administration of BHA to the pregnant mice (P generation) receiving 500 pg of DMBA would result in significant reduction in tumor risk among the individuals of F, generation ( p < 0.01) and F, generation ( p < 0.05).

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N-nitrosomethylurea (NMU) was administered once IP at a dose of 20 mg/kg to BD female rats on the 18th day of pregnancy. The first generation descendants (F1) were mated to produce a second generation (F2), which were then mated to produce a third generation (F3). While F1 rats were exposed directly