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Inhibitors selective for HDAC6 in enzymes and cells

✍ Scribed by Praveer K. Gupta; Robert C. Reid; Ligong Liu; Andrew J. Lucke; Steve A. Broomfield; Melanie R. Andrews; Matthew J. Sweet; David P. Fairlie

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
412 KB
Volume
20
Category
Article
ISSN
0960-894X

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✦ Synopsis

Histone deacetylase inhibitors with anticancer or anti-inflammatory activity bind to Class I or Class I and II HDAC enzymes. Here we compare selectivity of inhibitors of a Class II HDAC enzyme (HDAC6) and find one that retains high selectivity in macrophages.

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