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Inhibitors of β-Amyloid Formation Based on the β-Secretase Cleavage Site

✍ Scribed by G. Abbenante; D.M. Kovacs; D.L. Leung; D.J. Craik; R.E. Tanzi; D.P. Fairlie


Book ID
115585192
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
50 KB
Volume
268
Category
Article
ISSN
0006-291X

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BACE1 cleaves the amyloid precursor protein (APP) at the b-cleavage site (Met 671 -Asp 672 ) to initiate the generation of amyloid peptide Ab. BACE1 is also known to cleave APP at a much less well-characterized b 0 -cleavage site (Tyr 681 -Glu 682 ). We describe here the identification of a novel AP