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Inhibitors of the enkephalin degrading enzymes Modulation of activity of hydroxamate containing compounds by modifications of the C-terminal residue

✍ Scribed by XIE, J. ;SOLEILHAC, J.M. ;RENWART, N. ;PEYROUX, J. ;ROQUES, B.P. ;FOURNIÉ-ZALUSKI, M.C.


Book ID
115098901
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
778 KB
Volume
34
Category
Article
ISSN
0367-8377

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The role of lysines 37-39 (chymotrypsin numbering) in the 37-loop of the serine protease activated protein C (APC) was studied by expressing acidic and neutral recombinant APC (rAPC) mutants. Activity of the APC mutants was assessed using human plasma and plasma-purified and recombinant derivatives