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Inhibitors of sterol synthesis. An efficient and specific side chain oxidation of 3β-hydroxy-5α-cholest-8(14)-en-15-one. Facile access to its metabolites and analogs.

✍ Scribed by Josef E. Herz; Shankar Swaminathan; William K. Wilson; George J. Schroepfer Jr.

Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
291 KB
Volume
32
Category
Article
ISSN
0040-4039

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Inhibitors of sterol synthesis. Chemical
Inhibitors of sterol synthesis. Chemical synthesis and spectral properties of (25R)-5α-cholest-8(14)-ene-3β,15β,26-triol, a potential metabolite of 3β-hydroxy-5α-cholest-8(14)-en-15-one and its effects on 3-hydroxy-3-methylglutaryl-coenzyme A reductase in CHO-K1 cells
✍ Shankar Swaminathan; Frederick D. Pinkerton; William K. Wilson; George J. Schroe 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 570 KB

(25R)-5 alpha-Cholest-8(14)-ene-3 beta,15 beta,26-triol (III) was prepared by reduction of (25R)-3 beta,26-diacetoxy-5 alpha-cholest-8(14)-en-15-one with sodium borohydride followed by treatment of the crude product with lithium aluminium hydride. The trihydroxysterol III, a potential metabolite of

Inhibitors of sterol synthesis. Chemical
Inhibitors of sterol synthesis. Chemical syntheses and spectral properties of 26-oxygenated derivatives of 3β-hydroxy-5α-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells
✍ Abdul U. Siddiqui; William K. Wilson; Karen E. Ruecker; Frederick D. Pinkerton; 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 974 KB

26-Oxygenated derivatives of As04)-15-ketosterols have been synthesized from (25R)-3#,26-diacetoxy-5a-cholest-8( )-en-15-one (IX) as part of a program to prepare potential metabolites and analogs of 3/~-hydroxy-5c~-cholest-8( )-en-15-one (I), a potent regulator of cholesterol metabolism. Partial hyd