Calcium regulates progression through several checkpoints in the cell cycle, including the G1/S-phase transition, G2/M-phase transition, and exit from mitosis. In the GH4C1 rat pituitary cell line, calcium mobilizing polypeptides and calcium channel activation inhibit cell proliferation. This report
✦ LIBER ✦
Inhibitors of phosphatidylinositol 3-kinase activity prevent cell cycle progression and induce apoptosis at the M/G1 transition in CHO cells
✍ Scribed by A. van Opstal; J. Boonstra
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 277 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1420-682X
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## Abstract **Background:** Cell lines that stably over‐express protein kinase C (PKC) δ frequently show a decrease in growth rate and saturation density, leading to the hypothesis that PKCδ has a negative effect on cell proliferation. However, the mode of PKCδ activation, the cell cycle stage requ