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Inhibitors of osteoclastogenesis from Lawsonia inermis leaves

✍ Scribed by Nguyen Xuan Cuong; Nguyen Xuan Nhiem; Nguyen Phuong Thao; Nguyen Hoai Nam; Nguyen Tien Dat; Hoang Le Tuan Anh; Le Mai Huong; Phan Van Kiem; Chau Van Minh; Ji-Hee Won; Won-Yoon Chung; Young Ho Kim

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 286 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.06.118

No coin nor oath required. For personal study only.

✦ Synopsis

Ten phenolic compounds (1-10) were isolated from a methanol extract of Lawsonia inermis leaves including two new ones, lawsoniasides A (1) and B (2). Their structures were elucidated by spectroscopic methods (NMR and FTICRMS) in combination with acid hydrolysis and GC analyses. Compounds 4 and 5 showed a significant inhibition on receptor activator for nuclear factor-jB ligand-induced osteoclast formation in murine bone-marrow macrophages.

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