Inhibitors of blood coagulation factors Xa and IIa synergize to reduce thrombus weight and thrombin generation in vivo and in vitro

The syntheses and in vitro biotransforma

The syntheses and in vitro biotransformation studies of [14C]apixaban, a highly potent, selective, efficacious and orally bioavailable inhibitor of blood coagulation Factor Xa

✍ Brad D. Maxwell; Scott B. Tran; Shiang-Yuan Chen; Donglu Zhang; Bang-Chi Chen; H 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 223 KB 👁 1 views

## Abstract Apixaban is a potent inhibitor of blood coagulation Factor Xa in the late stages of development. [^14^C]apixaban was synthesized with the 14C label in the two different lactam ring systems within the molecule for various __in vitro__ and __in vivo__ metabolism studies. A nine‐step synth