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Inhibitors of Bcr-abl... breaking new ground again

✍ Scribed by Ohren, Jeffrey F; Sebolt-Leopold, Judith S


Book ID
109913583
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
185 KB
Volume
2
Category
Article
ISSN
1552-4450

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## Abstract Chronic myelogenous leukemia (CML) is a myeloproliferative disease associated with a defined genetic abnormality, the Bcr‐Abl fusion gene on the Philadelphia chromosome that expresses the constitutively activated tyrosine kinase (TK) Bcr‐Abl. This enzyme leads to the malignant transform