New insights into small-molecule inhibit
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S. Schenone; O. Bruno; M. Radi; M. Botta
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Article
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2010
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John Wiley and Sons
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English
β 427 KB
## Abstract Chronic myelogenous leukemia (CML) is a myeloproliferative disease associated with a defined genetic abnormality, the BcrβAbl fusion gene on the Philadelphia chromosome that expresses the constitutively activated tyrosine kinase (TK) BcrβAbl. This enzyme leads to the malignant transform