Catechol based inhibitors of 15-lipoxyge
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Bradley D. Tait; Richard D. Dyer; Bruce J. Auerbach; Dirk Bornemeier; Linda Guil
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Article
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1996
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Elsevier Science
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English
โ 185 KB
A potent 15-lipoxygenase (15-LO) inhibitor, compound 6, was identified by mass screening the Parke-Davis compound portfolio. The active moiety of compound 6 was determined to be the catechol functionality. Additional analogs were prepared and analyzed for inhibitory activity against 5-, 12-, and 15l