Inhibitors Designed for Presenilin 1 by
Inhibitors Designed for Presenilin 1 by Means of Aspartic Acid Activation. Preliminary Communication
β
Gregor Larbig; Andrea Zall; Boris Schmidt
π
Article
π
2004
π
John Wiley and Sons
π
German
β 168 KB
## Abstract __Ξ³__βSecretase, a multiprotein aspartic protease crucial to __Alzheimer__'s dementia, is not available for NMR experiments and has, so far, escaped crystallization. A positional scan of the aspartic protease by reactive probes may provide the necessary structural information for drug d