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Inhibitors (I) Designed for Presenilin 1 by Means of Aspartic Acid Activation.

✍ Scribed by Gregor Larbig; Andrea Zall; Boris Schmidt


Book ID
101967901
Publisher
John Wiley and Sons
Year
2005
Weight
11 KB
Volume
36
Category
Article
ISSN
0931-7597

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Inhibitors Designed for Presenilin 1 by
✍ Gregor Larbig; Andrea Zall; Boris Schmidt πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 German βš– 168 KB

## Abstract __Ξ³__‐Secretase, a multiprotein aspartic protease crucial to __Alzheimer__'s dementia, is not available for NMR experiments and has, so far, escaped crystallization. A positional scan of the aspartic protease by reactive probes may provide the necessary structural information for drug d