Inhibiton by different amino acids of the aspartate kinase and the homoserine kinase of the yeastSaccharomyces cerevisiae
✍ Scribed by Cayo Ramos; Marco A. Delgado; Isabel L. Calderon
- Book ID
- 115924423
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 431 KB
- Volume
- 278
- Category
- Article
- ISSN
- 0014-5793
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Aspartate kinase (EC 2.7.2.4.) has been purified from 7 day etiolated wheat (Triticum aestivum L. var. Maris Freeman) seedlings and from embryos imbibed for 8 h. The enzyme was 50% inhibited by 0.25 mM lysine. In this study wheat aspartate kinase was not inhibited by threonine alone or cooperatively
The HOM3 gene of Saccharomyces cerevisiae encodes aspartate kinase, which catalyses the first step in the branched pathway leading to the synthesis of threonine and methionine from aspartate. Regulation of the carbon flow into this pathway takes place mainly by feedback inhibition of this enzyme by