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Inhibition versus induction of apoptosis by proteasome inhibitors depends on concentration

✍ Scribed by Lin, Kuo-I; Baraban, Jay M; Ratan, Rajiv R

Book ID
110015791
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
418 KB
Volume
5
Category
Article
ISSN
1350-9047

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## Abstract The lysosomal apoptosis pathway is a potentially interesting therapeutic target. Since apoptosis involving the lysosomal pathway has been described to involve cathepsins, we screened a drug library for agents that induce cathepsin‐dependent apoptosis. Using pharmacological inhibitors an