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Inhibition Selectivity of Grapefruit Juice Components on Human Cytochromes P450

✍ Scribed by Wichittra Tassaneeyakul; Lian-Qing Guo; Katsuyuki Fukuda; Tomihisa Ohta; Yasushi Yamazoe


Book ID
115568241
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
126 KB
Volume
378
Category
Article
ISSN
0003-9861

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To investigate the potential interaction between selected ingredients of grapefruit juice and, the transport of talinolol, a P-gp substrate, across Caco-2 cells monolayers was determined in the absence and presence of distinct concentrations of grapefruit juice, bergamottin, 6 0 ,7 0 -dihydroxyberga