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Inhibition of β-Lactamases by Monocyclic Acyl Phosph(on)ates †

✍ Scribed by Kaur, Kamaljit; Adediran, S. A.; Lan, Martin J. K.; Pratt, R. F.

Book ID
127000683
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
155 KB
Volume
42
Category
Article
ISSN
0006-2960

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Inverse Acyl Phosph(on)ates: Substrates
Inverse Acyl Phosph(on)ates: Substrates or Inhibitors of β-Lactam-Recognizing Enzymes?
✍ Michael J. Morrison; Naixin Li; R.F. Pratt 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 155 KB

Acyl phosph(on)ates represent a new class of inhibitors of beta-lactam-recognizing enzymes. Previously described members of this class were aroyl phosph(on)ates. These compounds have been shown to acylate and/or phosphylate the active site serine residue, leading to either transient or essentially i