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Inhibition of VEGF transcription through blockade of the hypoxia inducible factor-1α–p300 interaction by a small molecule

✍ Scribed by Hyuk Sung Kwon; Da-Rae Kim; Eun Gyeong Yang; Yong Keun Park; Hee-Chul Ahn; Sun-Joon Min; Dae-Ro Ahn


Book ID
116318677
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
434 KB
Volume
22
Category
Article
ISSN
0960-894X

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✍ Peter Büchler; Howard A. Reber; Markus W. Büchler; Helmut Friess; Robert S. Lave 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 281 KB 👁 2 views

## Abstract ## BACKGROUND Previous reports indicate that Genistein, a naturally occurring isoflavonoid, exhibits strong antiangiogenic activity. The underlying mechanism of inhibition, however, remains unclear. Among the biologic effects of Genistein are the inhibition of tyrosine kinases and the