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Inhibition of tumour promotion by various palm-oil tocotrienols

✍ Scribed by S. H. Goh; N. F. Hew; A. W. Norhanom; M. Yadav

Book ID
102277209
Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
345 KB
Volume
57
Category
Article
ISSN
0020-7136

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✦ Synopsis

Inhibition of tumour promotion by various vitamin E compounds (tocopherols and tocotrienols) and some of their dimers was examined by an in vitro assay utilizing the activation of Epstein-Barr virus (EBV) early antigen (EA) expression in EBV-genome-carrying human lymphoblastoid cells. The results reveal that y-and 6-tocotrienols derived from palm oil exhibit a strong activity against tumour promotion by inhibiting EBV EA expression in Raji cells induced by I 2-0-tetradecanoylphorbol-13-acetate (TPA). However, a-and y-tocopherols and dimers of y-tocotrienol or y-tocopherol lack this activity.

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## Abstract Tocotrienol‐rich fraction (TRF) of palm oil has been shown to possess potent antioxidant, anticancer, and cholesterol lowering activities. In this study, our aim was to examine the effects of TRF on LPS‐induced inflammatory response through measuring the production of inflammatory media